Skip navigation

상단메뉴

글로벌메뉴

좌측메뉴

학술행사

검색

논문

tab menu

  • View
  • All
  • 수학부
  • 물리학부
  • 계산과학부
  • Center for Advanced Computation

Seminar View

Seminar
TITLE Polymer brush-induced depletion interactions and clustering of membrane proteins
KIAS AUTHORS Hyeon, Changbong,Tom, Anvy Moly,Kim, Won Kyu
JOURNAL JOURNAL OF CHEMICAL PHYSICS, 2021
ARCHIVE https://arxiv.org/abs/2102.12979
ABSTRACT We investigate the effect of mobile polymer brushes on proteins embedded in biological membranes by employing both Asakura-Oosawa type of theoretical model and coarse-grained molecular dynamics simulations. The brush polymer-induced depletion attraction between proteins changes non-monotonically with the size of brush. The depletion interaction, which is determined by the ratio of the protein size to the grafting distance between brush polymers, increases linearly with the brush size as long as the polymer brush height is shorter than the protein size. When the brush height exceeds the protein size, however, the depletion attraction among proteins is slightly reduced. We also explore the possibility of the brush polymer-induced assembly of a large protein cluster, which can be related to one of many molecular mechanisms underlying recent experimental observations of integrin nanocluster formation and signaling.
  • before page
  • list
  • next page
Seminar List

keyword

fiel&date

~