||The new Fermilab g-2 result has confirmed the previous measurement. The deviation to the SM prediction has now a significance of 4.2 sigma and the indications for physics beyond the SM (BSM) are strengthened. In the talk we discuss which BSM scenarios would be able to explain this deviation how such scenarios are constrained. A basic point to notice is that the deviation is larger than the contributions from the SM weak interactions. For this reason only BSM scenarios with specific enhancement mechanisms are able to accommodate the deviation, and such scenarios typically involve intriguing connections to the muon mass generation mechanism and/or to dark matter and are often strongly constrained by other experiments.